遗传开关
A genetic switch
Mark Ptashne、Klaus Dartmann · 初版 1986 年
3人推荐
4位读者提及
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“A Genetic Switch第一版已成为基因调控领域的经典论述，用简明的分子生物学语言解释了随着病毒lambda在细菌体内生长，蛋白质如何与DNA结合并开启或关闭基因。在微调后重印的原文基础上，作者增加了一章，阐述了拓展和深化我们对lambda‘genetic switch’理解的最新进展。对lambda的研究揭示了所有生物体转录调控背后的基本反应，并展示了这些反应如何组合形成复杂的调控回路。”
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……能够促进或抑制下游基因表达的酶。关于基因电路（genetic circuitry）到底能有多复杂，举一个（相对简单的）例子：如果谁不介意读点带点技术硬核的内容，我非常喜欢且推荐 Mark Ptashne 写的《A Genetic Switch: Phage Lambda》。免责声明：我不是生物学家，也很乐意听听比我更专业的人的见解，无论关于……
…enzymes that can promote or repress the expression of downstream genes. As just one (relative simple) example of how complicated genetic circuitry can be, I really enjoyed & recommend Mark Ptashne's A Genetic Switch: Phage Lambda for anyone who doesn't mind doing some slightly technical reading. Disclaimer: not a biologist, and would be interested in hearing from someone more knowledgeble than I, both about the…
这对我影响非常大……快速读完 Ptashne 的《A Genetic Switch》真正把我带进了分子生物学的大门。它们帮我开始建立起概念模型：一群没有生命的物体（比如蛋白质、脂质、核酸）是如何共同构成“生命体”，包括进行繁衍，以及……
This had great impact on me…and the quick read of Ptashne’s “a genetic switch” really pulled me into molecular biology. They helped me start to conceptualize how a group of inanimate objects (eg proteins, lipids, nucleic acid) can collectively be “alive”, including reproduce, and…
《A Genetic Switch》是我们领域里最好的书之一。整本书都在讲一种细菌病毒里的单个基因开关，从宏观概述一路讲到细枝末节的机理，全都是为了讲透这一个开关。……
“A Genetic Switch” is one of the best books in my field. The entire book is about a single genetic switch in a bacterial virus, starting off high level before going down into the nitty gritty, all for this single switch.…
<speculation> 1) 细胞共享大部分 DNA 序列 2) 细胞会根据环境改变自身行为（Mark Ptashne《A Genetic Switch: Phage Lambda Revisited》）（Mark Ptashne 与 Alexander Gann《Genes & Signals》） 3) 基因组编辑技术已经存在（Ali Movahedi《One Introduction of Genome Editing (CRISPR)》） 4) 改造酵母基因组……
<speculation> 1) cells share a large portion of DNA sequences 2) cells change their behavior based on their environment (Mark Ptashne "A Genetic Switch: Phage Lambda Revisited") (Mark Ptashne and Alexander Gann "Genes & Signals) 3) The technology exists to edit the genome (Ali Movahedi "One Introduction of Genome Editing (CRISPR)) 4) modify yeast genome…
……通过“定向进化”（directed evolution）它们开始互相合作 https://www.sciencedirect.com/science/article/pii/S200103702... 细胞内已经存在已知的执行开关控制的机制：https://www.amazon.com/Genetic-Switch-Third-Lambda-Revisited... 这种表观遗传形式使得对外部刺激做出各种有趣的反应成为可能。特别是，它允许提出“化学层面的问题”。完全有可能……
…through "directed evolution" they start to cooperate https://www.sciencedirect.com/science/article/pii/S200103702... There already is known machinery to do switching in cells: https://www.amazon.com/Genetic-Switch-Third-Lambda-Revisited... This form of epigenetics allows all kinds of interesting responses to external stimuli. In particular, it would allow "chemical questions" to be asked. It would be possible…