十亿美元的分子
The billion-dollar molecule
Barry Werth · 初版 1994 年
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《The Billion-Dollar Molecule》揭开了一家极具突破性的新兴生物医药公司内部波澜壮阔的精彩戏剧性幕布。这家名为Vertex的公司试图研发一种能拯救生命的新药——如果成功，不仅能证明一种颠覆性制药技术的巨大潜力，还将实现Vertex创始人兼董事长、同代人中最富潜力的科学家之一Joshua Boger的宏图夙愿。1989年初，时年三十七岁的Boger立志变革制药业这一现存利润最高的行业。他先后在Harvard和顶级生物医药公司Merck接受训练，
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再补充几本这里还没列出的：- 《The Billion Dollar Molecule》：讲述福泰制药（Vertex Pharmaceuticals）的故事及其全新的药物设计方法 - 《The Double Helix》：由主要参与科学家之一（沃森/Watson）讲述发现 DNA 结构的故事。更多……
To add some that haven't already been listed here: - The Billion Dollar Molecule: story of Vertex pharmaceuticals and their new approach to drug design - The Double Helix: story of the discovery of the structure of DNA by one of the principal scientists involved (Watson) More of…
我很喜欢《The Billion Dollar Molecule》这本书（《Nature》的评价在这里：https://www.nature.com/articles/nbt0594-521.pdf），讲述的是 Vertex Pharma（福泰制药）的创立过程。它真的让人切身感受到，要想取得突破，究竟需要耗费多少金钱、时间和运气——……
I loved the book The Billion Dollar Molecule (Reviewed by Nature here: https://www.nature.com/articles/nbt0594-521.pdf) about the founding of Vertex Pharma. Really drives home the amount of money, time and luck it takes to make a breakthrough -…
《The Billion Dollar Molecule》这本书讲的是 Vertex Pharma 的创立。值得一读。
The book "The Billion Dollar Molecule" is about the founding of Vertex Pharma. Worth a read.
……年前。当时有大篇幅文章报道 Vertex 应用自由能微扰（Free Energy Perturbation），还配有默克（Murcko）与戴维·珀尔曼（David Pearlman）及戈温达·比塞蒂（Govinda Bhisetti）的照片。甚至还有一本书专门记录了这些努力——《The Billion-Dollar Molecule》，最近还有一部续作，部分描写了 Vertex 使用这些方法遭遇失败的过程（《The Antidote》）。显然，自1989年以来计算能力已经提升了几个数量级。所以……
…years ago. Big articles were written about Vertex applying Free Energy Perturbation with pictures of Murcko accompanied by David Pearlman and Govinda Bhisetti. A book was written about these efforts, The Billion-Dollar Molecule, and more recently a sequel which partially describes how Vertex's efforts using these methods failed (The Antidote). Obviously, computational power has improved by orders of magnitude since 1989. So…
药物研发总体上属于一种“自然寡头垄断”……研发周期漫长且耗资巨大，但偶尔押中一个“赢家”就能带来几代人的收入。没记错的话（IIR），有一本关于该行业的书就叫《The Billion Dollar Molecule》。与此同时，美国一些富得让人恶心、富得离谱的家伙正在经营小型制药品牌，要么卖补剂要么卖关键药物。这种财富杠杆被公之于众是由于……
drug research overall falls into a "natural oligopoly" .. the research is lengthy and expensive, yet the occasional "winner" can be generations of income. IIR a book on the industry is called "The Billion Dollar Molecule" meanwhile, some of the obnoxiously, obscenely wealthy individuals in the USA are running small pharm brands, either supplements or critical medicines. This wealth-crowbar was exposed to the public by…