制药业的真相
The Truth about Drug Companies
Marcia Angell · 初版 2004 年
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为什么值得读
- 作者为新英格兰医学杂志前主编且视角专业
- 揭示药物临床试验与监管当中的腐败问题
- 包含详实的统计数据与针对性的改进建议
Angell 目睹了各大制药公司如何背离了研发和制造实用药物的初衷，转而演变为对其自身财富拥有空前掌控力的庞大营销机器。她看到它们对医学研究、教育以及医生的执业方式获得了几乎不受限制的影响力。而当美国公众、尤其是老年群体，在面对不断攀升的处方药价格而苦苦挣扎并越来越难以承受时，她深表同情。
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……原始数据会放在 clinicaltrials.gov 上，但其实几乎从不公开。同样有很多书解释了为什么会这样，我个人既喜欢《Overdosed America》（再提一次），也喜欢玛西亚·安吉尔（Marcia Angell）的书《The Truth About Drug Companies》。不过我敢肯定本·戈达克（Ben Goldacre）的新书大概也涵盖了同样的内容。“记住，和所有药物一样，两者的效果都取决于剂量，并且在联合服用时会有不良副作用……
…raw data is on clinicaltrials.gov which it almost never is. There are again a number of books that explain why this is, I personally like both Overdosed America (again) and also Marcia Angell's book The Truth About Drug Companies. I'm sure Ben Goldacre's new book probably covers the same stuff though. "eep in mind that, as with all drugs, both are dose-dependent and have unpleasant side-effects when taken in combination with…
……不作任何保证。仅仅因为某件事在理论上讲得通，并不意味着它在现实中就是真的。有很多书讲过药物试验存在的问题……比如本·戈达克的《Bad Pharma》、玛西亚·安吉尔的《The Truth About Drug Companies》、《Overdosed America》等等。这些书探讨的问题大多各有侧重，所以依我看全读一遍挺有价值的。
…guarantee of anything. Just because something makes sense on paper doesn't mean that it's actually true. There are a number of books about the issues with drug trials... Bad Pharma by Ben Goldacre, The Truth About Drug Companies by Marcia Angell, Overdosed America, etc. All of these books cover largely different issues, so imho it's worth reading them all.
……从公众利益出发，药物研发和测试应当在学术界进行。制药行业不应该参与其中，而应当仅仅负责生产已获批准的药物。补充：请参阅前《新英格兰医学杂志》（NEJM）编辑玛西亚·安吉尔医学博士所著的《The Truth About Drug Companies》。
…the public interest, drug discovery and testing ought to occur in academia. The pharmaceutical industry should play no role in that, and should merely manufacture approved drugs. Edit: Please see The Truth About Drug Companies, by Marcia Angell, M.D., formerly an editor of the New England Journal of Medicine.
……只要彻底整顿制药行业和 FDA 的所有腐败，一半的问题就能迎刃而解。我读过的两本书里对此都有相当详实的数据和建议：玛西亚·安吉尔的《The Truth About Drug Companies》和约翰·亚伯拉罕森的《Overdosed America》。问题多到根本列不完，但它们极其重要。第二件需要改变的事情是，我们需要更多关于……的数据
…half the problems you could get rid of just by cleaning up all the corruption in pharma and the FDA. The two books I've read that both have some pretty good stats and recommendations on this are: The Truth About Drug Companies by Marcia Angell Overdosed America by John Abramson The problems are way too numerous to list, but they're extremely important. The second thing that needs to change is that we need more data about…
……崩坏的体制。我读过这本书，觉得相当令人大开眼界。我没有逐一核实读到的所有内容，但我确实去查证过的那些部分都与书中的说法一致……http://www.amazon.com/Truth-About-Drug-Companies-Deceive/dp/...
…brokenness. I read this book, and found it quite eye opening. I haven't checked up on everything that I read about, but the things I did look into were consistent with the claims... http://www.amazon.com/Truth-About-Drug-Companies-Deceive/dp/...
NEJM 的前主编曾写过一本叫《The Truth About Drug Companies》的书，里面对此有非常详尽的描述。还有《The Emperors New Drugs》和《Overdosed America》这两本书。第一本是讲 4 期临床试验的，另外几本探讨的则是 1 到 3 期临床试验更普遍存在的问题……
The former head editor of NEJM wrote a book called The Truth About Drug Companies that describes it in good detail. Also the book The Emperors New Drugs and the book Overdosed America. The first is about phase 4 trials, the other books cover more general issues with phase 1-3 trials…