破天机
A Crack in Creation
Jennifer A. Doudna、Samuel H. Sternberg · 初版 2017 年
4人推荐
7位读者提及
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一位开创先河的生物学家，努力应对自己在当代最重大科学发现中所扮演的角色：一种廉价、简便重写基因密码的方法，伴随着近乎无限的希望与危险。自原子弹问世以来，从未有一项技术让其发明者如此警惕，以至于向全世界就其使用发出警告。直到 2015 年春，生物学家 Jennifer Doudna 呼吁全球暂停使用新型基因编辑工具 CRISPR——一项由她协助创立的革命性新技术——来进行人类胚胎的可遗传修饰。这是操作
Hacker News 上怎么说
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……不过当它把不可能变成可能时，那也只是个注脚了。但我们确实得继续探讨这些伦理问题，这样才能明智地运用这项工具。想进一步了解的话，我推荐 Jennifer Doudna 的《A Crack in Creation》。她是将 CRISPR 作为基因编辑工具的奠基人之一，她写的这本书是关于该主题的绝佳读物。
…footnote when it makes the impossible, possible though. We need to keep having these ethics conversations though, so we can use this tool wisely. For further reading I would recommend Jennifer Doudna's "A crack in creation". She is one of the founders of CRISPR as a gene editing tool, and her book is good reading on the topic.
……导致其他问题？是的。> 这类研究会让未来的人类寿命延长两到三倍吗？是的。> 只需要现在一小部分的粮食供应？是的。我建议任何感兴趣的人都去读读 Jennifer Doudna 博士写的《A Crack in Creation》。
…causing others? Yes. >Could this type of research lead to a time when humans live two to three times as long? Yes. > Need a fraction of our current food supply? Yes. I suggest anyone interested read A Crack in Creation, by Dr. Jennifer Doudna.
……面向所有人的未来 4. 《四巨头：Amazon、Apple、Facebook 和 Google 的隐秘 DNA》 5. 《这个想法棒极了：每个人都该知道的被遗忘、被忽视和被低估的科学概念》 6. 《A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution》 7. 《东方化：从奥巴马到特朗普时代的亚洲崛起与美国衰落》 8. 《给忙碌者的天体物理学》 9. 《那个曾经……》
…Future for Everyone 4. The Four: The Hidden DNA of Amazon, Apple, Facebook, and Google 5. This Idea Is Brilliant: Lost, Overlooked, and Underappreciated Scientific Concepts Everyone Should Know 6. A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution 7. Easternization: Asia’s Rise and America’s Decline from Obama to Trump and Beyond 8. Astrophysics for People in a Hurry 9. The Woman Who…
对想了解更多的人，我强烈推荐 Doudna 的书《A Crack in Creation》——通俗易懂地解释了发现 CRISPR/Cas9 的整个过程。https://www.amazon.co.uk/Crack-Creation-Editing-Unthinkable-...
For anyone interested in learning more, I highly recommend Doudna’s book, “A Crack in Creation” - very readable explanation of the process leading to discovering CRISPR/Cas9. https://www.amazon.co.uk/Crack-Creation-Editing-Unthinkable-...
Doudna 自己写了回忆录《A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution》。明明能直接从科学家本人那里获取第一手信息，干嘛还要去看 Isaacson 的第三人称转述呢？好吧，反正这两本书我都读了，……
Doudna has her own memoir, "A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution." Why would you read Isaacson's third-person account, when you can get the information from the scientist herself? Well, I read both books,…
> Jennifer Doudna 对灾难性生物差错（bioerror）的概率怎么看？你可以在她的书《A Crack in Creation》里找到她（以及合著者 Sam Sternberg）对将 CRISPR 作为一种制造生物差错手段的看法。
>What does Jennifer Doudna think of the probability of catastrophic bioerror? You can find hers (and co-author Sam Sternberg's) opinion on CRISPR as a method to do bioerror in her book "A Crack in Creation".